MANCHESTER, England -- Manchester City faces a new injury concern for Kevin de Bruyne ahead of a showdown with Premier League title rival Arsenal after the playmaker was substituted at halftime of Wednesday's Champions League match against Inter Milan.

The Belgium international looked in discomfort late in the first half and after receiving treatment he didn't return for the second half, with Ilkay Gundogan coming on his place. The game ended 0-0.

City hosts title rival Arsenal at Etihad Stadium on Sunday.

De Bruyne endured an injury-disrupted campaign last season when he was sidelined from August to January with a hamstring problem. He returned to help the club secure a record fourth straight English title.

He has started every game this season and scored in City's 4-1 win against Ipswich last month.

City held off challenges from Arsenal in each of the last two seasons to lift the title. The north London club is expected to be City's main rival again this term.

Arsenal has its own injury problems ahead of the game after captain Martin Odegaard was ruled out with ankle ligament damage.

Without De Bruyne, City failed to find a breakthrough against Inter and was shut out at home in the Champions League for the first time since a 0-0 draw with Sporting Lisbon in March 2022.

It was only the second time in all competitions since then that Guardiola's team failed to score at home -- the other coming in a 0-0 with Arsenal in the league in March.

City extended its unbeaten home run in European games to 32, dating back to a 2-1 loss to Lyon in 2018.

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James Robson is at https://twitter.com/jamesalanrobson